cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil

Int J Cancer. 1998 Oct 5;78(2):135-9. doi: 10.1002/(sici)1097-0215(19981005)78:2<135::aid-ijc1>3.0.co;2-#.

Abstract

To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Bacterial*
  • Bacterial Proteins / genetics*
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Genes, Bacterial
  • Helicobacter Infections / complications*
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Stomach Neoplasms / microbiology*

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • cagA protein, Helicobacter pylori