Background: Deep or infiltrating lipoma is an often misdiagnosed clinical entity. We report two typical cases.
Case reports: Two women, aged 92 and 62 years, were seen for a tumefaction on an upper limb with progressively increasing volume. The clinical presentation suggested deep lipoma, confirmed by magnetic resonance imaging and histology which eliminated liposarcoma, the main differential diagnosis. Surgical excision was successful. There has been no recurrence.
Discussion: These two observations recall the clinical, diagnostic and therapeutic features of infiltrating lipoma.