Cbfa1 in bone development

Curr Opin Genet Dev. 1998 Aug;8(4):494-9. doi: 10.1016/s0959-437x(98)80123-8.

Abstract

A factor fundamental to bone formation has been identified. Gene targeting shows that core-binding factor alpha 1 (Cbfa1) plays an essential role in bone formation and osteoblast differentiation. Thus, it is now possible to begin examining the molecular mechanism of bone formation--especially osteoblast differentiation.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Development*
  • Cell Differentiation
  • Cleidocranial Dysplasia / genetics
  • Core Binding Factor Alpha 1 Subunit
  • Core Binding Factors
  • Gene Expression
  • Humans
  • Mice
  • Mutation
  • Neoplasm Proteins*
  • Osteoblasts / cytology
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Core Binding Factor Alpha 1 Subunit
  • Core Binding Factors
  • Neoplasm Proteins
  • Transcription Factors