Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice

J Ethnopharmacol. 1998 Aug;62(1):57-61. doi: 10.1016/s0378-8741(98)00044-0.

Abstract

Neuropharmacological studies were carried out with reticuline, a benzylisoquinoline alkaloid, isolated from Ocotea duckei Vattimo. It was found that reticuline (50-100 mg/kg i.p.) produced alteration of behaviour pattern, prolongation of pentobarbital-induced sleep, reduction in motor coordination and D-amphetamine-induced hypermotility and suppression of the conditioned avoidance response. These observations suggest that reticuline possesses potent central nervous system depressant action.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / administration & dosage
  • Alkaloids / pharmacology*
  • Amphetamine / pharmacology
  • Animals
  • Avoidance Learning / drug effects
  • Benzylisoquinolines*
  • Central Nervous System Depressants / administration & dosage
  • Central Nervous System Depressants / pharmacology*
  • Dopamine Antagonists / administration & dosage
  • Dopamine Antagonists / pharmacology*
  • Injections, Intraventricular
  • Isoquinolines / administration & dosage
  • Isoquinolines / pharmacology*
  • Male
  • Mice
  • Motor Activity / drug effects
  • Pentobarbital / pharmacology
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry*
  • Rats
  • Rats, Wistar
  • Sleep / drug effects

Substances

  • Alkaloids
  • Benzylisoquinolines
  • Central Nervous System Depressants
  • Dopamine Antagonists
  • Isoquinolines
  • Plant Extracts
  • Amphetamine
  • Pentobarbital
  • reticuline