Triple therapy with methotrexate, sulfasalazine, and hydroxychloroquine in patients with rheumatoid arthritis

Rheum Dis Clin North Am. 1998 Aug;24(3):465-77. doi: 10.1016/s0889-857x(05)70020-x.

Abstract

Combinations of DMARDs are currently used to treat rheumatoid arthritis by almost all rheumatologists. This article reviews the published data on the triple combination of methotrexate, sulfasalazine, and hydroxychloroquine, discusses caveats for clinical use, compares efficacy of different combinations, and speculates on future combination therapies.

Publication types

  • Review

MeSH terms

  • Antirheumatic Agents / administration & dosage*
  • Arthritis, Rheumatoid / drug therapy*
  • Cyclosporine / administration & dosage
  • Drug Therapy, Combination
  • Humans
  • Hydroxychloroquine / administration & dosage*
  • Methotrexate / administration & dosage*
  • Sulfasalazine / administration & dosage*
  • Treatment Outcome

Substances

  • Antirheumatic Agents
  • Sulfasalazine
  • Hydroxychloroquine
  • Cyclosporine
  • Methotrexate