Abstract
Transcription factors play a key role in determination of the fate of the cells in osteoblastic and chondrocytic lineage. A runt family member, Cbfa, is indispensable for osteoblastic differentiation. Sox 9 and scleraxis are involved in the phenotypic expression in chondrocytes and the cells of early stage connective tissues. These transcription factors will give us a clue to unravel interaction of these known and yet unknown transcription factors to fully understand the mechanisms of skeletal cells ' differentiation and regulation of their functions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / physiology
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Core Binding Factor Alpha 1 Subunit / physiology
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Core Binding Factor beta Subunit / physiology
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High Mobility Group Proteins / physiology
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Mice
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Mice, Knockout
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Osteoblasts / physiology*
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SOX9 Transcription Factor
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Transcription Factors / physiology*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Core Binding Factor Alpha 1 Subunit
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Core Binding Factor beta Subunit
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High Mobility Group Proteins
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SOX9 Transcription Factor
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Scx protein, mouse
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Sox9 protein, mouse
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Transcription Factors