Sinoaortic denervation produces sodium retention in Dahl salt-sensitive rats

J Auton Nerv Syst. 1998 Mar 3;69(1):56-63. doi: 10.1016/s0165-1838(98)00008-3.

Abstract

The role of the arterial baroafferent signals in sodium (Na) homeostasis was examined in salt-sensitive rats. Sodium balances, water balances, and systolic arterial pressure (SAP) were measured for 3 weeks in sinoaortic denervated (SAD) or sham denervated (Sham) Dahl salt-sensitive (S) and salt-resistant (R) rats fed a standard-salt diet (0.4% NaCl). In R rats, there was no significant difference in Na balance, water balance, or SAP between the SAD and Sham animals. In the S rats, urinary Na excretion was suppressed in the SAD but not in the Sham animals, resulting in Na retention. SAD significantly increased SAP and mean arterial pressure. High salt challenge (8% NaCl diet) markedly increased SAP and Na and water balances in both S-SAD and S-Sham rats. However, no significant difference was found in SAP or cumulative Na and water balances between S-SAD and S-Sham rats. These results suggest that the baroafferent signals may have some role on the regulation of Na balance in salt-sensitive animals under a standard-salt condition, although a high-salt load masked the baroafferent-dependent sodium excretion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Body Weight / drug effects
  • Denervation*
  • Diet
  • Drug Resistance / physiology
  • Male
  • Osmolar Concentration
  • Rats
  • Rats, Inbred Strains / physiology
  • Sinus of Valsalva / innervation*
  • Sodium / blood
  • Sodium Chloride / administration & dosage
  • Sodium Chloride / pharmacology*
  • Water / metabolism

Substances

  • Water
  • Sodium Chloride
  • Sodium