In orthodontic treatment employing arch guided tooth movement, rectangular wires are usually used to achieve three-dimensional controlled tooth movement. In the intention to optimize sliding mechanics and to improve the comfort of patients, edge beveled rectangular orthodontic wires are offered by different manufacturers. The objective of the study presented was to investigate the influence of differing but defined wire roundings on sliding mechanics of canine retraction. Employing the 0.018" slot system, 0.016" x 0.022" standard steel wires (Remaloy and Remanium, Dentaurum Comp.) were tested. Force loss due to friction during canine retraction was determined using the Orthodontic Measurement and Simulation System (OMSS). In the arch guided distalization of canines, the average loss of force caused by friction was determined to be approximately 50%. Comparing wires with different edge bevel, the rounded wire in contrast to the wire with sharpest edge configuration results in a reduction of friction. Even a moderate wire rounding of the 0.016" x 0.022" steel wire results in about 10% reduction in frictional losses. However, dynamic analysis of tooth movement with the OMSS shows that there is no further improvement of sliding mechanics using wires with edge bevel exceeding the standard rounding of rectangular wires. In contrast, a strong edge bevel may result in a considerable loss of leveling.