Mode of action of torilin in multidrug-resistant cancer cell lines

Planta Med. 1998 May;64(4):335-8. doi: 10.1055/s-2006-957446.

Abstract

The mechanism of action of multidrug-resistance reversing activity of torilin was studied. In vitro experiments for the accumulation and efflux of vinblastine clearly indicated that MDR reversing effects of torilin would directly be associated with the increase of the intracellular accumulation of anticancer drugs by blocking the drug efflux. Furthermore, torilin increased the membrane ATPase activity from KB-V1 cells, suggesting that torilin might function by inhibiting drug transport mediated by P-glycoprotein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Adenosine Triphosphatases / metabolism
  • Antineoplastic Agents, Phytogenic / metabolism
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Biological Transport
  • Cell Membrane / enzymology
  • Drug Resistance, Multiple*
  • Drug Resistance, Neoplasm*
  • Drug Synergism
  • Humans
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes, Guaiane
  • Tumor Cells, Cultured
  • Verapamil / metabolism
  • Verapamil / pharmacology
  • Vinblastine / metabolism
  • Vinblastine / pharmacology

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes
  • Sesquiterpenes, Guaiane
  • Vinblastine
  • Verapamil
  • Adenosine Triphosphatases
  • torilin