Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production

J Med Chem. 1998 May 21;41(11):1745-8. doi: 10.1021/jm970849z.
No abstract available

MeSH terms

  • Crystallography, X-Ray
  • Humans
  • Hydroxamic Acids / blood
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / chemistry
  • Hydroxamic Acids / pharmacology
  • In Vitro Techniques
  • Lactams / blood
  • Lactams / chemical synthesis*
  • Lactams / chemistry
  • Lactams / pharmacology
  • Lipopolysaccharides / blood
  • Lipopolysaccharides / pharmacology
  • Lymphocyte Activation
  • Matrix Metalloproteinase 1
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase Inhibitors
  • Metalloendopeptidases / antagonists & inhibitors*
  • Metalloendopeptidases / blood
  • Models, Molecular
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Hydroxamic Acids
  • Lactams
  • Lipopolysaccharides
  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • SC 903
  • SE 205
  • Tumor Necrosis Factor-alpha
  • Metalloendopeptidases
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 1