Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity

Adv Exp Med Biol. 1998:431:293-8. doi: 10.1007/978-1-4615-5381-6_58.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Alternative Splicing
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Base Sequence
  • Breast Neoplasms / drug therapy*
  • Chemotherapy, Adjuvant
  • Dihydrouracil Dehydrogenase (NADP)
  • Exons
  • Female
  • Fluorouracil / administration & dosage
  • Fluorouracil / adverse effects*
  • Heterozygote*
  • Humans
  • Introns
  • Leukocytes, Mononuclear / enzymology
  • Middle Aged
  • Oxidoreductases / biosynthesis
  • Oxidoreductases / blood
  • Oxidoreductases / genetics*
  • Point Mutation*
  • Polymerase Chain Reaction
  • RNA, Messenger / biosynthesis
  • Tamoxifen / administration & dosage
  • Transcription, Genetic

Substances

  • RNA, Messenger
  • Tamoxifen
  • Oxidoreductases
  • Dihydrouracil Dehydrogenase (NADP)
  • Fluorouracil