Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for rheumatic conditions. Their effects on the upper gastrointestinal tract are well recognised. Clinically important damage to the small intestines is less common and often unrecognised. We report a case of sulindac-induced jejunal perforation in a rheumatoid arthritis (RA) patient with previous gastrectomy for gastric carcinoma. The prevalence, diagnosis, pathogenesis and treatment options of NSAID-induced enteropathy will be discussed.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Arthritis, Rheumatoid / diagnosis
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Arthritis, Rheumatoid / drug therapy
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Disease-Free Survival
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Enteritis / chemically induced
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Humans
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Intestinal Perforation / chemically induced*
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Intestinal Perforation / diagnostic imaging
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Intestinal Perforation / surgery
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Jejunal Diseases / chemically induced*
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Jejunal Diseases / diagnostic imaging
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Jejunal Diseases / surgery
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Male
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Middle Aged
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Sulindac / adverse effects*
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Sulindac / therapeutic use
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Tomography, X-Ray Computed
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Sulindac