Effect of shape, size, and valency of multivalent mannosides on their binding properties to phytohemagglutinins

Glycoconj J. 1998 Mar;15(3):251-63. doi: 10.1023/a:1006945028547.

Abstract

Clusters of di-, tri-, and tetra-antennary alpha-D-mannopyranosides were synthesized in good yields based on the coupling of amine-bearing mono- or trisaccharide [Man alpha(1 --> 6)[Man alpha(1 --> 3)]Man] haptens to poly-isocyanate or -isothiocyanate tethering cores. The relative binding properties of the resulting multivalent ligands were determined by turbidimetric and solid phase enzyme-linked lectin assays (ELLA) using plant lectins (phytohemagglutinins) Concanavalin A (Con A) and Pisum sativum (pea lectin) having four and two carbohydrate binding sites, respectively. Rapid and efficient cross-linking between tetravalent Con A and mannopyranosylated clusters were measured by a microtiter plate version of turbidimetric analyses. In inhibition of binding of the lectins to yeast mannan, the best tetravalent monosaccharide (30) and trisaccharide (31) inhibitors were shown to be 140 and 1155 times more potent inhibitors than monomeric methyl alpha-D-mannopyranoside against pea lectin and Con A, respectively. Compounds 30 and 31 were thus 35- and 289-fold more potent than the reference monosaccharide based on their hapten contents. As a general observation, the ligands bearing the Man alpha(1 --> 6)[Man alpha(1 --> 3)]Man trimannoside structures were found to be more potent inhibitors for Con A than the ligands having single mannoside residues, whereas pea lectin could not discriminate between the two types of ligands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Carbohydrate Sequence
  • Concanavalin A / chemistry
  • Concanavalin A / metabolism
  • Lectins / chemistry
  • Lectins / metabolism
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Mannosides / chemical synthesis
  • Mannosides / chemistry*
  • Mannosides / metabolism*
  • Molecular Sequence Data
  • Molecular Structure
  • Phytohemagglutinins / chemistry
  • Phytohemagglutinins / metabolism*
  • Plant Lectins*

Substances

  • Lectins
  • Ligands
  • Mannosides
  • Phytohemagglutinins
  • Plant Lectins
  • pea lectin
  • Concanavalin A