Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia

Brain Res Mol Brain Res. 1998 Mar 1;54(2):212-8. doi: 10.1016/s0169-328x(97)00337-9.

Abstract

To investigate the biological roles of the presenilin-1 (PS-1) gene after neuronal injury, the changes of PS-1 mRNA expression in the gerbil hippocampus after transient ischemia were examined. From 1 day to 3 day-reperfusion after 5 min-ischemia, PS-1 mRNA was induced in the hippocampus compared with the sham-operated control. The cells which induced the PS-1 genes were neurons of CA3 and dentate gyrus, the region relatively resistant to ischemic stress. These findings suggest that the induction of PS-1 genes may be associated with some responses of neurons damaged by transient ischemia.

MeSH terms

  • Alzheimer Disease / genetics*
  • Animals
  • Blotting, Northern
  • Gerbillinae
  • Glyceraldehyde-3-Phosphate Dehydrogenases / analysis
  • Hippocampus / blood supply
  • Hippocampus / metabolism*
  • In Situ Hybridization
  • Ischemic Attack, Transient / metabolism*
  • Ischemic Attack, Transient / pathology
  • Male
  • Membrane Proteins / genetics*
  • Membrane Proteins / physiology
  • Neurons / metabolism*
  • Neurons / pathology
  • Presenilin-1
  • Reperfusion

Substances

  • Membrane Proteins
  • Presenilin-1
  • Glyceraldehyde-3-Phosphate Dehydrogenases