Abstract
The molecular basis of redox sensitivity in proteins is not well understood. Here we consider a continuum of NO- and O2-related modifications of cysteine residues that constitute biological signaling events on the one hand and hallmarks of nitrosative and oxidative stresses on the other.
Publication types
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Comment
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News
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cysteine*
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Glutathione / analogs & derivatives
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Glutathione / pharmacology
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Glutathione Reductase / chemistry
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Glutathione Reductase / metabolism
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Humans
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Nitric Oxide*
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Nitroso Compounds / pharmacology*
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Oxidation-Reduction
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Oxidative Stress*
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Oxygen*
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Protein Processing, Post-Translational
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Proteins / chemistry*
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S-Nitrosoglutathione
Substances
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Nitroso Compounds
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Proteins
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Nitric Oxide
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S-Nitrosoglutathione
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Glutathione Reductase
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Glutathione
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Cysteine
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Oxygen