Decreased energy demanding processes in the frontal lobes of schizophrenics due to neuroleptics? A 31P-magneto-resonance spectroscopic study

Psychiatry Res. 1997 Dec 30;76(2-3):123-9. doi: 10.1016/s0925-4927(97)00047-4.

Abstract

In the present investigation on 31P-magneto-resonance spectroscopic parameters in the frontal lobe, we found phosphocreatine levels and the ratio phosphocreatine/adenosine triphosphate to be increased (12.62 +/- 1.98% resp. 0.31 +/- 0.06) in 50 neuroleptic-treated schizophrenics, whereas no differences were detected in 10 neuroleptic-free patients (11.66 +/- 2.57% resp. 0.29 +/- 0.08) compared to 36 controls (11.37 +/- 1.45 resp. 0.29 +/- 0.04). This result points to a major role of neuroleptics in the metabolism of high-energy phosphates.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Adult
  • Antipsychotic Agents / pharmacology*
  • Antipsychotic Agents / therapeutic use
  • Brief Psychiatric Rating Scale
  • Female
  • Frontal Lobe / drug effects*
  • Frontal Lobe / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Male
  • Middle Aged
  • Phosphocreatine / metabolism*
  • Phosphorus*
  • Schizophrenia / drug therapy
  • Schizophrenia / metabolism*

Substances

  • Antipsychotic Agents
  • Phosphocreatine
  • Phosphorus
  • Adenosine Triphosphate