Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced microencephaly

Brain Res. 1998 Mar 23;787(2):333-6. doi: 10.1016/s0006-8993(97)01489-3.

Abstract

Methylazoxymethanol (MAM)-induced cortical hypoplasia resulted in a 20% decrease in the Bmax of 5-HT2A receptors in the frontal cortex with no change in the Bmax of 5-HT1A receptors. Chronic treatment with amitriptyline did not further decrease the Bmax of 5-HT2A receptors in the MAM-lesioned cortex, suggesting that the persistent down-regulation of cortical 5-HT2A receptors in MAM-lesioned rats was induced by serotonergic hyperinnervation.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
  • Alkylating Agents*
  • Amitriptyline / pharmacology*
  • Animals
  • Antidepressive Agents, Tricyclic / pharmacology*
  • Behavior, Animal / drug effects
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Female
  • Ketanserin / metabolism
  • Ketanserin / pharmacology
  • Kinetics
  • Male
  • Methylazoxymethanol Acetate / analogs & derivatives*
  • Microcephaly / chemically induced
  • Microcephaly / metabolism*
  • Pregnancy
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin / drug effects*
  • Serotonin Antagonists / pharmacology
  • Serotonin Receptor Agonists / pharmacology

Substances

  • Alkylating Agents
  • Antidepressive Agents, Tricyclic
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Amitriptyline
  • Methylazoxymethanol Acetate
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Ketanserin
  • methylazoxymethanol