Splicing: HACking into the unfolded-protein response

C E Shamu

doi:10.1016/s0960-9822(98)70986-8

Splicing: HACking into the unfolded-protein response

Curr Biol. 1998 Feb 12;8(4):R121-3. doi: 10.1016/s0960-9822(98)70986-8.

Author

C E Shamu¹

Affiliation

¹ Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

PMID: 9501974
DOI: 10.1016/s0960-9822(98)70986-8

Abstract

Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-specific RNase activity, and tRNA ligase.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Basic-Leucine Zipper Transcription Factors
Fungal Proteins / metabolism*
Protein Biosynthesis
Protein Folding*
RNA Splicing*
RNA, Messenger / genetics
Repressor Proteins / metabolism*
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins*
Transcription Factors / metabolism*

Substances

Basic-Leucine Zipper Transcription Factors
Fungal Proteins
HAC1 protein, S cerevisiae
RNA, Messenger
Repressor Proteins
Saccharomyces cerevisiae Proteins
Transcription Factors