Abstract
We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti-Hu syndrome."
MeSH terms
-
Alleles
-
Autoantibodies / blood*
-
Autoimmune Diseases / immunology*
-
Carcinoma, Small Cell / genetics
-
Carcinoma, Small Cell / immunology*
-
Cytotoxicity, Immunologic
-
HLA-A Antigens / genetics
-
HLA-B Antigens / genetics
-
HLA-DR Antigens / genetics
-
HLA-DRB1 Chains
-
Histocompatibility Testing
-
Humans
-
Lung Neoplasms / genetics
-
Lung Neoplasms / immunology*
-
Nervous System Diseases / genetics
-
Nervous System Diseases / immunology*
-
Paraneoplastic Syndromes / immunology*
Substances
-
Autoantibodies
-
HLA-A Antigens
-
HLA-B Antigens
-
HLA-DR Antigens
-
HLA-DRB1 Chains