Comparative linkage mapping of genes on sheep chromosome 3 provides evidence of chromosomal rearrangements in the evolution of the Bovidae

Cytogenet Cell Genet. 1997;78(3-4):272-4. doi: 10.1159/000134670.

Abstract

Three genes--parathyroid hormone-like hormone (PTHLH), insulin-like growth factor 1 (IGF 1), and retinoic acid receptor gamma (RARG)--have been mapped to sheep (Ovis aries) chromosome 3 (OAR 3). The order and genetic distances between loci on OAR 3 are similar to those on cattle (Bos taurus) chromosome 5, as expected from their close evolutionary relationship. The OAR 3 linkage map shows conserved synteny with human chromosome 12, but there are at least two rearrangements in gene order between the species.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle / genetics*
  • Chromosome Mapping
  • Evolution, Molecular*
  • Gene Rearrangement*
  • Genetic Linkage*
  • Hair Follicle
  • Parathyroid Hormone / genetics
  • Parathyroid Hormone-Related Protein
  • Polymorphism, Restriction Fragment Length
  • Proteins / genetics
  • Receptors, Retinoic Acid / genetics
  • Retinoic Acid Receptor gamma
  • Sheep / genetics*
  • Species Specificity
  • Wool

Substances

  • Parathyroid Hormone
  • Parathyroid Hormone-Related Protein
  • Proteins
  • Receptors, Retinoic Acid