Abstract
Bone marrow cell responsiveness to hematopoietic growth factors was investigated in rats only confined or experiencing inescapable, escapable shocks or no electric shock. The results demonstrated a significant reduction in the number of granulocyte-macrophage precursors in the bone marrow of confined rats and of rats exposed to inescapable shocks. The reversibility of this mielossupressive response was seen in both groups and occurred first in the confined animals. No changes were observed in the group submitted to escapable shocks when compared to controls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Marrow Cells / cytology
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Bone Marrow Cells / drug effects*
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Bone Marrow Cells / physiology*
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Cell Differentiation / drug effects
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Cell Differentiation / physiology
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Cell Division / drug effects
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Cell Division / physiology
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Electroshock
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Female
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Granulocytes / cytology
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Hematopoietic Cell Growth Factors / pharmacology*
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Hematopoietic Stem Cells / cytology
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Hematopoietic Stem Cells / drug effects
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Macrophages / cytology
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Rats
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Rats, Wistar
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Stress, Physiological / physiopathology
Substances
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Hematopoietic Cell Growth Factors