Abstract
The mechanism of action of auromomycin was studied with intact cells of Bacillus subtilis. The antibiotic exhibited a preferential inhibition of DNA synthesis over RNA and protein syntheses. The strand scission of cellular DNA was induced by the drug, and DNA was degraded into acid-soluble fragments. The results suggested that DNA is the chemoreceptor of auromomycin.
MeSH terms
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Anti-Bacterial Agents*
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Antibiotics, Antineoplastic / pharmacology*
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Bacillus subtilis / drug effects*
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Bacillus subtilis / growth & development
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Bacillus subtilis / metabolism
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Bacterial Proteins / biosynthesis
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DNA, Bacterial / metabolism
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DNA, Single-Stranded / metabolism
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Peptides / pharmacology
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RNA, Bacterial / biosynthesis
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Bacterial Proteins
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DNA, Bacterial
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DNA, Single-Stranded
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Peptides
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RNA, Bacterial
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auromomycin