We reported a rare case of isolated tricuspid valve endocarditis in a non-addict with no underlying cardiac disease. A 48-year-old man was presented with high fever and newly developed leg edema. The diagnosis of tricuspid endocarditis was established following detection of a large vegetation (3.0 cm) on the tricuspid valve on echocardiography. One blood culture showed positive for Campylobacter fetus. At operation, a large and a small vegetation were found attached to the anterior leaflet of the tricuspid valve, and the septal leaflet was also found to be involved by the infective endocarditis. These leaflets were therefore removed and the tricuspid valve was replaced with CarboMedics valve. He has remained free of endocarditis for nineteen months after surgery.