Radiation dosimetry for indium-111-pentetreotide

J Nucl Med. 1997 Dec;38(12):1919-22.

Abstract

We present radiation dose estimates for 111In-pentetreotide.

Methods: Kinetic data were gathered in 10 subjects at two different sites. A compartmental model was used to fit the data, including retention, in three major organs and excretion.

Results: The data were consistent for the subjects at both sites. The organ receiving the highest dose was the kidneys (0.52 mGy/MBq); the effective dose equivalent was 0.1 mSv/MBq, and the effective dose was 0.073 mSv/MBq.

Conclusion: The results of this study provide the basis for evaluation of radiation safety of this drug.

Publication types

  • Multicenter Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Child
  • Computer Simulation
  • Female
  • Humans
  • Indium Radioisotopes* / pharmacokinetics
  • Kidney / radiation effects
  • Male
  • Octreotide / analogs & derivatives*
  • Octreotide / pharmacokinetics
  • Pentetic Acid / analogs & derivatives*
  • Pentetic Acid / pharmacokinetics
  • Pregnancy
  • Radiation Dosage
  • Radiation Protection*
  • Radiopharmaceuticals* / pharmacokinetics
  • Tissue Distribution
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Indium Radioisotopes
  • Radiopharmaceuticals
  • SDZ 215-811
  • Pentetic Acid
  • Octreotide