Osteoporosis, one of the most prevalent diseases associated with aging, is characterized by a low bone mass and microarchitectural deterioration of bone tissue leading to increased susceptibility of fracture. The management of osteoporotic patients relies especially on the static measurement of bone mass as bone mineral and dynamic changes of bone turn over. New developments of bone mineral density measurement techniques and biochemical markers of bone turnover are reviewed. Their clinical uses for the management of patients with osteoporosis are discussed.