Thymic B-cell non-Hodgkin's lymphoma in a child

Am J Hematol. 1998 Jan;57(1):48-50. doi: 10.1002/(sici)1096-8652(199801)57:1<48::aid-ajh8>3.0.co;2-1.

Abstract

A 13-year-old male developed thymic non-Hodgkin's lymphoma. Microscopically, the tumor was composed of large cells, resembling centroblasts. Immunohistochemically, the tumor demonstrated leukocyte common antigen+, L26 (B-cell)+, UCHL1 (T-cell)-, suggesting the B-cell phenotype. In contrast to the terminally differentiated phenotype (CD10-, surface immunoglobulin-) observed in adult cases, flow cytometric analysis showed that they were relatively immature: CD10+, CD19+, HLA-DR-, IgM+/-, kappa+. He was successfully treated with intensive chemotherapy. Since childhood thymic lymphomas are exclusively small non-cleaved cell lymphoma with T-cell phenotype, this case represents a unique entity in children.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Humans
  • Immunophenotyping
  • Lymphoma, Non-Hodgkin / diagnostic imaging
  • Lymphoma, Non-Hodgkin / pathology*
  • Male
  • Mediastinal Neoplasms / diagnostic imaging
  • Mediastinal Neoplasms / pathology*
  • Thymus Neoplasms / diagnostic imaging
  • Thymus Neoplasms / pathology*
  • Tomography, X-Ray Computed