Enhancement of cytotoxic activity by synthesis of peptide multimeric forms

Anticancer Res. 1997 Sep-Oct;17(5A):3609-11.

Abstract

Synthesis of four multimeric H-Lys-His-His-Arg-Lys-Lys-His-Arg-Lys-Arg-Lys-His-His-Lys-Arg-Lys-oH peptides containing two, four, eight and sixteen branches was carried out by solid phase utilizing a lysine core matrix. These multimeric peptides enhanced activity by inhibiting the colony-forming ability of HeLa cells, from twenty-four to fifty-six times in comparison with the monomeric form. Unexpectedly the peptide with only two-branched sequences showed the highest inhibitory activity.

MeSH terms

  • Amino Acid Sequence
  • Cell Division / drug effects
  • Growth Inhibitors / chemical synthesis*
  • Growth Inhibitors / chemistry
  • HeLa Cells
  • Humans
  • Lysine / chemistry
  • Molecular Sequence Data
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / pharmacology
  • Structure-Activity Relationship

Substances

  • Growth Inhibitors
  • Oligopeptides
  • Lysine