Abstract
The effects of glucocorticoids on acute pancreatitis are a matter of dispute. In animal experiments, dexamethasone and hydrocortisone significantly decreased the serum amylase activities 8 hours after the induction of pancreatitis. In the dexamethasone treated group, the serum IL-6 level was significantly decreased at 4 and 8 hours, while in the hydrocortisone treated group, all the IL-6 values were significantly diminished vs. the control group. As compared to the control, a glucocorticoid antagonist (RU 38486) did not influence the serum amylase activity, but significantly increased the serum IL-6 level. These results suggest that glucocorticoids may play a role in the control of pancreatitis caused by inhibition of cytokine production.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Amylases / blood
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Animals
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Anti-Inflammatory Agents / antagonists & inhibitors
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Anti-Inflammatory Agents / therapeutic use
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Dexamethasone / antagonists & inhibitors
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Dexamethasone / therapeutic use
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Glucocorticoids / antagonists & inhibitors
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Glucocorticoids / therapeutic use*
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Hormone Antagonists / therapeutic use*
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Hydrocortisone / antagonists & inhibitors
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Hydrocortisone / therapeutic use
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Interleukin-6 / antagonists & inhibitors
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Interleukin-6 / blood
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Mifepristone / therapeutic use*
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Pancreatitis / drug therapy*
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Rats
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Time Factors
Substances
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Anti-Inflammatory Agents
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Glucocorticoids
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Hormone Antagonists
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Interleukin-6
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Mifepristone
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Dexamethasone
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Amylases
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Hydrocortisone