Insulin-dependent diabetes mellitus presenting with ketoalkalosis in Rett syndrome

Diabet Med. 1997 Oct;14(10):884-5. doi: 10.1002/(SICI)1096-9136(199710)14:10<884::AID-DIA453>3.0.CO;2-#.

Abstract

A 9-year-old girl with Rett syndrome presented with typical symptoms of insulin-dependent diabetes mellitus. Upon investigation she was found to have a primary respiratory alkalosis associated with diabetes ketoacidaemia. Once non-ketotic normoglycaemia was achieved her respiratory alkalosis persisted. This was felt to be due to an abnormal breathing pattern of hyperventilation punctuated by apnoeas which is associated with Rett syndrome.

Publication types

  • Case Reports

MeSH terms

  • Alkalosis / blood
  • Alkalosis / etiology
  • Apnea
  • Bicarbonates / blood
  • Carbon Dioxide / blood
  • Child
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetic Ketoacidosis / blood
  • Diabetic Ketoacidosis / diagnosis*
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Hyperventilation
  • Oxygen / blood
  • Partial Pressure
  • Respiration
  • Rett Syndrome / complications*
  • Rett Syndrome / physiopathology*

Substances

  • Bicarbonates
  • Carbon Dioxide
  • Oxygen