Coccidioidomycosis is described in seven California sea lions (Zalophus californianus) admitted to The Marine Mammal Center, Sausalito, California (USA), between January 1986 and December 1994. Diagnoses were confirmed by histology in all seven cases, culture in three cases, and serology in one case. These are believed to be the first published cases of coccidioidomycosis in free-ranging California sea lions.