Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

N Kato; K H Lan; S K Ono-Nita; Y Shiratori; M Omata

doi:10.1128/JVI.71.11.8856-8859.1997

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

J Virol. 1997 Nov;71(11):8856-9. doi: 10.1128/JVI.71.11.8856-8859.1997.

Authors

N Kato¹, K H Lan, S K Ono-Nita, Y Shiratori, M Omata

Affiliation

¹ Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. kato-2im@h.u-tokyo.ac.jp

Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

MeSH terms

Amino Acid Sequence
Female
Gene Expression Regulation, Viral*
Hepatitis C / genetics*
Hepatitis C / virology
Humans
Ions
Male
Molecular Sequence Data
Trans-Activators / genetics*
Transcription Factors / genetics*
Transcription, Genetic
Transcriptional Activation
Viral Nonstructural Proteins / genetics*

Substances

Ions
Trans-Activators
Transcription Factors
Viral Nonstructural Proteins
NS-5 protein, hepatitis C virus