Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease

T Facon; J P Jouet; M P Noel-Walter; F Bloget; F Bauters; A Janin

doi:10.1038/sj.bmt.1700912

Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease

Bone Marrow Transplant. 1997 Sep;20(6):511-5. doi: 10.1038/sj.bmt.1700912.

Authors

T Facon¹, J P Jouet, M P Noel-Walter, F Bloget, F Bauters, A Janin

Affiliation

¹ Unité Régionale de Greffe de Moelle Osseuse, CHRU Lille, France.

PMID: 9313887
DOI: 10.1038/sj.bmt.1700912

Abstract

We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bone Marrow Transplantation
Child
Fatal Outcome
Female
Graft vs Host Disease / immunology
Graft vs Host Disease / pathology*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / immunology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
Leukemia, Myeloid, Acute / immunology
Leukemia, Myeloid, Acute / pathology
Leukemia, Myeloid, Acute / therapy
Macrophages / metabolism*
Macrophages / physiology
Middle Aged
Tumor Necrosis Factor-alpha / metabolism*
Tumor Necrosis Factor-alpha / physiology

Substances

Tumor Necrosis Factor-alpha