[Clinical utility of available diagnostic tests in prostatic carcinoma. Results of 500 biopsies. I. PSA, PSA density, and predicted PSA]

Arch Esp Urol. 1997 May;50(4):333-8.
[Article in Spanish]

Abstract

Objective: To study the utility of PSA density and predicted PSA results in the diagnosis of prostatic cancer using gland volume.

Methods: 500 patients suspected as having prostatic cancer underwent ultrasound-guided transrectal biopsy. Prostate volume and ultrasound characteristics, serum PSA density, predicted PSA and the difference between both were determined.

Results: 44.8% of the patients showed evidence of cancer in the biopsy specimen. These patients had a significantly smaller prostate. The 0.1 and 0.15 PSA density cutoffs had a sensitivity of 96% and 94%, specificity of 10% and 20% and positive predictive value of 46% and 49%, respectively. The statistical values for PSA difference of 1 and 2 were 94% and 92%, 13% and 18%, 47% and 48%, respectively.

Conclusion: PSA density and predicted PSA results could be useful to avoid biopsies in patients with PSA between 4 and 10 ng/ml and no malignant tumor of the prostate.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / blood
  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / diagnostic imaging
  • Adenocarcinoma / pathology
  • Biomarkers, Tumor / blood*
  • Biopsy, Needle*
  • Diagnosis, Differential
  • Evaluation Studies as Topic
  • Humans
  • Male
  • Organ Size
  • Predictive Value of Tests
  • Prospective Studies
  • Prostate / diagnostic imaging
  • Prostate / pathology*
  • Prostate-Specific Antigen / blood*
  • Prostatic Hyperplasia / diagnosis
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / diagnostic imaging
  • Prostatic Neoplasms / pathology
  • Sensitivity and Specificity
  • Ultrasonography

Substances

  • Biomarkers, Tumor
  • Prostate-Specific Antigen