Abstract
Overexpression of Alzheimer amyloid precursor protein (APP) produces dramatically different phenotypes in transgenic mice depending on the genetic background. For example, concentrations of APP that produce amyloid plaques in outbred transgenic lines are lethal for inbred FVB/N or C57BL/6J mice. Expression of SOD1 transgenes is protective, suggesting involvement of oxidative damage in premature death, but ablation of Apoe had no significant effect. In contrast, FGF2 transgene overexpression enhances the lethal effects of APP. Differential survival does not appear to reflect genetic differences in APP processing, but rather host responses to APP or its derivatives.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amyloid beta-Protein Precursor / genetics*
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Amyloid beta-Protein Precursor / metabolism
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Amyloid beta-Protein Precursor / physiology
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Animals
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Apolipoproteins E / genetics
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Fibroblast Growth Factor 2 / genetics
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Fibroblast Growth Factor 2 / metabolism
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Gene Deletion
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Gene Expression
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Genes, Lethal
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Mice
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Mice, Inbred C3H
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Mice, Inbred C57BL
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Mice, Transgenic
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Phenotype
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Protein Processing, Post-Translational
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Superoxide Dismutase / genetics
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Superoxide Dismutase / metabolism
Substances
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Amyloid beta-Protein Precursor
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Apolipoproteins E
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Fibroblast Growth Factor 2
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Superoxide Dismutase