Activation of mitogen-activated protein kinase cascade in diabetic glomeruli and mesangial cells cultured under high glucose conditions

Kidney Int Suppl. 1997 Sep:60:S66-9.

Authors

M Haneda¹, S Araki, M Togawa, T Sugimoto, M Isono, R Kikkawa

Affiliation

¹ Third Department of Medicine, Shiga University of Medical Science, Japan. haneda@belle.shiga-med.ac.jp

PMID: 9285905

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors
Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
Cells, Cultured
Cytosol / enzymology
Diabetic Nephropathies / enzymology*
Enzyme Activation
Enzyme Inhibitors / pharmacology
Flavonoids / pharmacology
Glomerular Mesangium / cytology*
Glomerular Mesangium / drug effects
Glomerular Mesangium / enzymology
Glucose / pharmacology*
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases*
Phospholipases A / metabolism
Rats
Rats, Sprague-Dawley

Substances

Enzyme Inhibitors
Flavonoids
Calcium-Calmodulin-Dependent Protein Kinases
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases
Phospholipases A
Glucose
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one