Apheresis therapy for prolonged red cell aplasia after major ABO-mismatched bone marrow transplantation

Intern Med. 1997 Jul;36(7):487-91. doi: 10.2169/internalmedicine.36.487.

Abstract

Two cases of leukemia were treated successfully with apheresis for delayed recovery of erythropoiesis due to antibody-mediated red cell aplasia after ABO-mismatched bone marrow transplantation (BMT). A 25-year-old female (ABO group O) underwent BMT from her brother (group A). Immunoadsorption using Biosynsorb A performed on day 146 after BMT followed by double filtration plasma pheresis (DFPP) reduced anti-A antibody titers from 1:32 to 1:2. Anemia improved dramatically within 2 weeks. A 49-year-old female (group O) underwent BMT from her mother (group A). She was treated with DFPP on day 131 after BMT. Anti-A antibody titers dropped from 1:16 to 1:1 and anemia improved gradually.

Publication types

  • Case Reports

MeSH terms

  • ABO Blood-Group System / immunology*
  • Adult
  • Blood Group Incompatibility / complications*
  • Bone Marrow Transplantation / adverse effects*
  • Bone Marrow Transplantation / immunology
  • Female
  • Host vs Graft Reaction / immunology*
  • Humans
  • Immunosorbent Techniques*
  • Isoantibodies / immunology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Leukemia, Myeloid, Acute / therapy
  • Male
  • Middle Aged
  • Plasmapheresis*
  • Red-Cell Aplasia, Pure / etiology
  • Red-Cell Aplasia, Pure / immunology
  • Red-Cell Aplasia, Pure / therapy*
  • Transplantation, Homologous

Substances

  • ABO Blood-Group System
  • Isoantibodies