Effects of orthographic neighborhood in visual word recognition in Spanish were examined in 5 paradigms: progressive demasking, standard lexical decision, lexical decision with blocking of neighborhood density, naming, and semantic categorization. The results showed inhibitory effects of neighborhood frequency in the progressive-demasking task, in both lexical-decision tasks, as well as for low-density words in the naming task, and for high-density words in the semantic-categorization task. Higher levels of neighborhood density produced an inhibitory trend in the progressive-demasking task, facilitation in lexical decision (significant only when neighborhood density was blocked), and a robust facilitation effect in naming (only for words with higher frequency neighbors). A global analysis across tasks and one simulation study helped outline some of the underlying task-specific and task-independent mechanisms.