[The anti-edematous effect of the preparation polyosm in acute hypertensive encephalopathy]

Eksp Klin Farmakol. 1997 Mar-Apr;60(2):72-4.
[Article in Russian]

Abstract

Experiments were conducted on Wistar rats to study the effect of intravenous infusion of polyosm (solution of polyethyleneoxide 400) on the parameters of brain tissue edema-swelling (according to impedancemetry findings) and the local cerebral blood flow on a model of acute hypertensive encephalopathy. Under such conditions the drug hastened involution of edema-swelling of the brain tissue and prevented a decrease in cerebral blood flow.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Animals
  • Brain Edema / chemically induced
  • Brain Edema / drug therapy*
  • Disease Models, Animal
  • Diuretics, Osmotic / therapeutic use*
  • Drug Evaluation, Preclinical
  • Hypertension / chemically induced
  • Hypertension / drug therapy*
  • Male
  • Norepinephrine
  • Papaverine / analogs & derivatives
  • Polyethylene Glycols / therapeutic use*
  • Rats
  • Rats, Wistar
  • Statistics, Nonparametric

Substances

  • Diuretics, Osmotic
  • Polyethylene Glycols
  • drotaverin
  • Papaverine
  • Norepinephrine