NK cells, macrophages, and humoral immune responses are dominant in primary nonfunction of islet grafts in the dog-to-rat xenotransplant model

Transplant Proc. 1997 Jun;29(4):2062-3. doi: 10.1016/s0041-1345(97)00232-7.

Authors

S Deng¹, R J Ketchum, T Kucher, M Weber, A Naji, K L Brayman

Affiliation

¹ Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA.

PMID: 9193527
DOI: 10.1016/s0041-1345(97)00232-7

No abstract available

MeSH terms

Animals
Antibodies, Monoclonal
Antibody Formation
Antilymphocyte Serum / pharmacology
B-Lymphocytes / immunology*
Blood Glucose / metabolism
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Diabetes Mellitus, Experimental / blood
Diabetes Mellitus, Experimental / surgery*
Dogs
Gadolinium / pharmacology
Graft Survival / physiology
Guanidines / pharmacology
Immunosuppressive Agents / pharmacology
Islets of Langerhans / immunology*
Islets of Langerhans / pathology
Killer Cells, Natural / immunology*
Macrophages / immunology*
Rats
Rats, Inbred Lew
Rats, Nude
Transplantation, Heterologous / immunology*
Transplantation, Heterologous / pathology

Substances

Antibodies, Monoclonal
Antilymphocyte Serum
Blood Glucose
Guanidines
Immunosuppressive Agents
Gadolinium
pimagedine