Targeted gene therapy for cancer: herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells

Biochem Soc Trans. 1997 May;25(2):717-22. doi: 10.1042/bst0250717.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Antiviral Agents / therapeutic use*
  • Cytokines / biosynthesis*
  • Ganciclovir / therapeutic use
  • Gene Transfer Techniques
  • Genetic Therapy / methods*
  • Genetic Vectors
  • Humans
  • Immunotherapy / methods
  • Inflammation
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Simplexvirus / enzymology
  • Simplexvirus / genetics*
  • T-Lymphocytes / immunology
  • Thymidine Kinase / biosynthesis*
  • Thymidine Kinase / genetics

Substances

  • Antiviral Agents
  • Cytokines
  • Thymidine Kinase
  • Ganciclovir