Sixty-seven lymphangiograms were performed in 58 patients with chronic lymphocytic leukemia. These patients were classified according to a new anatomico-clinical staging system which has previously been shown to bear prognostic significance. The lymphangiograms were divided into four groups on the basis of lymph node size and each group was further divided into subgroups (12). Each subgroup corresponded to a different roentgenographic picture. A good correlation was observed between lymphangiographic and anatomico-clinical staging: lymphangiogram groups 3 and 4, anatomico-clinical stage III and IV (p less than 0.001). The absence of normal lymph nodes in all patients, the diversity of lymphangiographic appearance from one patient to another and even the diversity from one region to another in the same patient should be stressed.