17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action

J Med Chem. 1997 May 23;40(11):1561-4. doi: 10.1021/jm970162e.
No abstract available

MeSH terms

  • Androstanols / chemical synthesis*
  • Androstanols / pharmacology
  • Androstanols / therapeutic use
  • Animals
  • Antihypertensive Agents / chemical synthesis*
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / drug effects
  • Enzyme Inhibitors
  • Hypertension / drug therapy
  • Kinetics
  • Molecular Structure
  • Ouabain / metabolism
  • Ouabain / pharmacology
  • Rats
  • Rats, Mutant Strains
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
  • Sodium-Potassium-Exchanging ATPase / metabolism

Substances

  • Androstanols
  • Antihypertensive Agents
  • Enzyme Inhibitors
  • Ouabain
  • Sodium-Potassium-Exchanging ATPase
  • rostafuroxin