Absence of human herpesvirus 8 genomes in coronary atherosclerosis in immunocompetent patients

Am J Cardiol. 1997 May 1;79(9):1245-7. doi: 10.1016/s0002-9149(97)00091-x.

Abstract

Human herpevirus 8 (HHV8) has been localized to the endothelial and spindle cells of KS, suggesting a role for HHV8 in atherosclerosis. None of the 38 coronary atherectomy specimens contained HHV8 with both sensitive nested PCR assays, making it unlikely that persistent viral infection with HHV8 plays a role in coronary atherogenesis in the general population of the United States.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • Coronary Artery Disease / immunology
  • Coronary Artery Disease / virology*
  • DNA, Viral / analysis
  • Herpesvirus 8, Human / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Sensitivity and Specificity

Substances

  • DNA, Viral