Aggressive gastric peripheral T-cell lymphoma of CD8+ type associated with lymphomatous meningitis

Mod Pathol. 1997 May;10(5):504-9.

Abstract

Most gastric lymphomas are of B-cell origin, and many are either low-grade or high-grade B-cell lymphomas of mucosa-associated lymphoid tissue type. Gastric T-cell lymphomas are very rare, usually of CD4+ type, and few have had genotypic studies. We report the case of a gastric peripheral T-cell lymphoma of CD8+ type. Genotypic studies demonstrated partial deletion with rearrangement of the T-cell receptor beta-chain gene. Lymphomatous meningitis developed, and the patient died after only 2 months despite chemotherapy. The case is compared with the other gastric T-cell lymphomas that have been reported.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antigens, CD20 / analysis
  • Biomarkers / analysis
  • Biopsy
  • CD3 Complex / analysis
  • CD8 Antigens / analysis*
  • Central Nervous System Neoplasms / secondary
  • Fatal Outcome
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphoma, T-Cell, Peripheral / chemistry
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Male
  • Meningitis / pathology
  • Stomach Neoplasms / pathology*

Substances

  • Antigens, CD20
  • Biomarkers
  • CD3 Complex
  • CD8 Antigens