Control conditions in the fear-potentiated startle response paradigm

Neuroreport. 1997 Mar 3;8(4):1031-4. doi: 10.1097/00001756-199703030-00042.

Abstract

In the present study, the fear-potentiated startle response paradigm was modified in order to investigate the decrease in control startle levels often observed after administration of anxiolytic drugs. The within-animal comparison of control startle amplitudes and fear-potentiated startle amplitudes normally used was replaced by a between-animal comparison. Moreover, the experimental design was extended with an additional control group, a no-shock group. The anxiolytics diazepam and chlordiazepoxide were used as pharmacological tools. The main findings were that both benzodiazepines dose-dependently reduced control startle amplitudes and no-shock startle amplitudes equally, suggesting that shock-associated contextual cues are not responsible for the drug-induced decrease in control startle amplitudes in the fear-potentiated startle response paradigm.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology
  • Chlordiazepoxide / pharmacology*
  • Diazepam / pharmacology*
  • Electroshock
  • Fear / drug effects
  • Fear / physiology*
  • Male
  • Models, Neurological
  • Models, Psychological
  • Rats
  • Rats, Wistar
  • Reflex, Startle / drug effects
  • Reflex, Startle / physiology*

Substances

  • Anti-Anxiety Agents
  • Chlordiazepoxide
  • Diazepam