A 42 year old physician doctor presented with temporary tinnitus after a first dose of a hepatitis B vaccination (Engerix B*). One month after, a fluctuant sensori-neural hearing loss with tinnitus appeared few hours after a second dose of hepatitis B vaccination (Engerix B*). The auditory thresholds varied from 45 dBHL and 0 dBHL for low frequencies below 1.5 kHz. The fluctuant hearing loss and tinnitus disappeared after a 6 month course.