Molecular mimicry between Helicobacter pylori and the host

B J Appelmelk; R Negrini; A P Moran; E J Kuipers

doi:10.1016/S0966-842X(96)10084-6

Molecular mimicry between Helicobacter pylori and the host

Trends Microbiol. 1997 Feb;5(2):70-3. doi: 10.1016/S0966-842X(96)10084-6.

Authors

B J Appelmelk¹, R Negrini, A P Moran, E J Kuipers

Affiliation

¹ Dept of Medical Microbiology, Vrije Universiteit, Amsterdam, The Netherlands. bj.appelmelk.mm@med.vu.nl

PMID: 9108933
DOI: 10.1016/S0966-842X(96)10084-6

Abstract

Helicobacter pylori lipopolysaccharide (LPS) expresses Lewis x and Lewis y blood group antigens that are identical to those occurring in the human gastric mucosa. During infection, antibodies against LPS, which bind to host Lewis antigens, may be induced. These consequently recognize gastric glycoprotein targets and cause autoimmune inflammation.

Publication types

Review

MeSH terms

Animals
Antibodies, Monoclonal / biosynthesis
Autoantibodies / biosynthesis
Bacterial Proteins / genetics
Bacterial Proteins / immunology
Gastric Mucosa / immunology
Helicobacter Infections / etiology
Helicobacter Infections / immunology
Helicobacter Infections / pathology
Helicobacter pylori / genetics
Helicobacter pylori / immunology*
Helicobacter pylori / pathogenicity
Humans
Lewis Blood Group Antigens / immunology
Lipopolysaccharides / immunology
Mice
Molecular Mimicry*

Substances

Antibodies, Monoclonal
Autoantibodies
Bacterial Proteins
Lewis Blood Group Antigens
Lipopolysaccharides