High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu

Lancet. 1997 Mar 29;349(9056):921-2. doi: 10.1016/S0140-6736(05)62696-7.
No abstract available

Publication types

  • Letter

MeSH terms

  • Alleles
  • Antimalarials / metabolism*
  • Aryl Hydrocarbon Hydroxylases*
  • Chemoprevention
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 Enzyme System / genetics*
  • Gene Frequency
  • Genotype
  • Humans
  • Malaria, Falciparum / prevention & control
  • Mixed Function Oxygenases / genetics*
  • Mutation*
  • Polymerase Chain Reaction
  • Proguanil / metabolism*
  • Vanuatu

Substances

  • Antimalarials
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Proguanil