Cellular fibrous histiocytoma of the skin: evidence of a clonal process with different karyotype from dermatofibrosarcoma

Genes Chromosomes Cancer. 1997 Apr;18(4):314-7. doi: 10.1002/(sici)1098-2264(199704)18:4<314::aid-gcc11>3.0.co;2-g.

Abstract

Recently, a distinct variant of cutaneous fibrous histiocytoma (FH) has been histologically characterized as a "cellular" subtype. This variant is often mistaken for sarcoma, including dermatofibrosarcoma protuberans. We report a case of cellular FH of the skin in which the cytogenetic analysis demonstrated a novel chromosome pattern, possibly allowing distinction from its histologic simulants.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 17
  • Chromosomes, Human, Pair 22
  • Dermatofibrosarcoma / genetics*
  • Dermatofibrosarcoma / pathology
  • Diagnosis, Differential
  • Female
  • Histiocytoma, Benign Fibrous / genetics*
  • Histiocytoma, Benign Fibrous / pathology
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology