Role of dopamine D1- and NMDA receptors in regulating neurotensin release in the striatum and nucleus accumbens

Brain Res. 1997 Feb 14;748(1-2):241-4. doi: 10.1016/s0006-8993(96)01380-7.

Abstract

Stimulation of dopamine D1-receptors by SKF 82958 increased extracellular neurotensin (NT) levels in the striatum and nucleus accumbens as measured by in vivo microdialysis while blockade of D1-receptors had no effect. Antagonism of NMDA receptors with MK 801 completely prevented the increased NT release induced by D1-stimulation in both structures. Tissue content of striatal NT anterior and posterior to the microdialysis probe was oppositely altered by D1-stimulation: increases were observed in the anterior striatum with decreased NT levels in the posterior striatum.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Corpus Striatum / metabolism*
  • Dizocilpine Maleate / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • Male
  • Microdialysis
  • Neurotensin / metabolism*
  • Nucleus Accumbens / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 / physiology*
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / physiology*

Substances

  • Excitatory Amino Acid Antagonists
  • Receptors, Dopamine D1
  • Receptors, N-Methyl-D-Aspartate
  • Neurotensin
  • Dizocilpine Maleate